The 16-Week Titration Protocol

Wegovy uses a carefully designed 16-week titration schedule that gradually increases your dose. This gradual approach minimizes side effects while allowing your body to adjust to the medication optimally.

Week-by-Week Dosing Schedule

Weeks 1-4: Starting Dose (0.25mg)

• Dose: 0.25mg subcutaneous injection once weekly
• Timing: Any day of the week preferred; maintain consistency
• Administration: Small 29-gauge needle, subcutaneous into abdomen, thigh, or upper arm
• Purpose: Allow your body to acclimate to the medication
• What to Expect: Minimal side effects; appetite reduction begins

Weeks 5-8: First Increase (0.5mg)

• Dose: 0.5mg weekly
• Side Effects: May be slightly more pronounced but improving overall
• Effects: Noticeable appetite reduction becomes apparent
• Weight Loss: Minimal weight loss usually observed

Weeks 9-12: Second Increase (1.0mg)

• Dose: 1.0mg weekly
• Effects: Noticeable weight loss becomes apparent
• Appetite: Most patients report significant hunger reduction
• Motivation: Visible progress increases motivation

Weeks 13-16: Third Increase (1.7mg)

• Dose: 1.7mg weekly
• Approach: Near-final therapeutic dose
• Effects: Enhanced weight loss effects maximized

Weeks 17+: Maintenance Phase (2.4mg)

• Dose: 2.4mg weekly (maximum therapeutic dose)
• Duration: Continue indefinitely for sustained weight loss
• Flexibility: May remain on lower doses (1.7mg) if well-tolerated and effective
• Stability: Dosing becomes routine and predictable

Personalizing Your Dosing Schedule

Not everyone advances to 2.4mg. Your healthcare provider may recommend:

• Staying on a lower dose if experiencing significant side effects
• Remaining on 1.7mg if weight loss is adequate and well-tolerated
• Pausing dose escalation temporarily if adjusting to side effects
• Extending titration timeline if needed for tolerance

Proper Injection Technique

• Use room temperature injection (more comfortable than cold)
• Rotate injection sites to prevent lipodystrophy (fat changes)
• Inject at same time each week for consistency
• Allow 30-60 minute wait after injection before eating
• Never inject into scar tissue or areas with lipodystrophy

What to Track During Titration

• Weight loss (weigh weekly or bi-weekly)
• Appetite changes and satiety improvements
• Energy levels and mood
• Side effect severity and trends
• Compliance with exercise plan
• Dietary habits and portion control

Storage and Stability Guidelines

• Storage: Keep at 2-8°C (refrigerated)
• Room Temperature: Can be kept at room temperature for up to 30 days
• Never Freeze: Freezing damages the medication
• After First Use: Use pen within 30 days even if refrigerated
• Travel: Use portable coolers for travel; pens remain stable